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Strain Registration

Strain: BHD/Dspe

Symbol: BHD/Dspe
Strain: BHD
Substrain: Dspe
Full Name: Birt-Hogg-Dube rat
RGD ID: 4139889
Citation ID: RRID:RGD_4139889
Ontology ID: RS:0002440
Alleles: Flcn
Also Known As: NBRP Rat No: 0577; Nihon rat
Type: inbred
Available Source: National BioResource Project for the Rat in Japan
Origination: National BioResource Project for the Rat in Japan
Description: A rat showing hereditary renal cell carcinoma was found in a Jcl:SD rat colony and named Nihon rat. In this rat strain mutation was identified as an insertion of a cytosine (C) in a C tract within exon 3 of Flcn . This germline mutation results in a frameshift and produces a stop codon 26 amino-acids downstream. Thereafter they have been maintained at Dainippon Sumitomo Pharma Co., Ltd.
Coat Color: Albino
Inbred Generations: F28
Last Known Status: Cryopreserved Embryo (as of 2018-06-06)






References

References - curated
# Reference Title Reference Citation
1. A novel "Nihon" rat model of a Mendelian dominantly inherited renal cell carcinoma. Okimoto K, etal., Jpn J Cancer Res 2000 Nov;91(11):1096-9.
2. A germ-line insertion in the Birt-Hogg-Dube (BHD) gene gives rise to the Nihon rat model of inherited renal cancer. Okimoto K, etal., Proc Natl Acad Sci U S A 2004 Feb 17;101(7):2023-7. Epub 2004 Feb 09.
3. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
null Hereditary renal cell carcinoma (RCC) model. A model rat for human Birt-Hogg-Dub?? (BHD) syndrome, characterized by fibrofolliculoma, spontaneous pneumothorax and renal neoplasm.